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An alternative cause of "atrophic" hypothyroidism is the development of thyroid stimulation blocking antibodies (TSBAb), which, as the name implies, prevent TSH binding to TSH-R, but do not stimulate thyroid cells and produce hypothyroidism

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Denatured semaglutide does not become poisonous

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Alebrahim MA, et al

Treatment with semaglutide tablets 14 mg once daily for 26 weeks resulted in a statistically significant reduction in HbA1c from baseline compared to placebo (see Table 8)